β£Description of NOF/ FCDSkeletally immature!L: distal tibia, metaphyseal, eccentricA: lytic, soap bubble appearanceR: narrow, no periosteal reactionM: scleroticβ£What is a NOF?It is an area of bone with faulty ossification rather than a true neoplasmβ£What is the incidence?30% of children with open physis have a NOF!β£Where does NOF occur?Metaphysis of lone bones80% lower extremity Distal femur > proximal tibiaβ£What is histology of NOF?storiform benign fibroblasts with multinucleated giant cellsβ£Any associated syndromes with NOF?Jaffe Campanacci Syndrome (very few cases reported about 18 in the world in 2012). Triad ofCafe au lait pigmentation;multiple NOFmental retardationyang2012.pdf1140.9KBβ£Management of NOF?Observe - Most resolve spontaneously by 2nd, 3rd decadeSurgical - Curettage and Bone GraftingIndications - symptomatic, large lesion, risk of #